MIPS Project Detail:
Company
Company Description:
FiberCell Systems offers hollow fiber bioreactor systems to academic and biotechnology markets. The company’s bioreactors utilize new, state-of-the-art filtration rates that offer many advantages over conventional cell culture methods, and are used by NASA at the International Space Station and endorsed by the European Medicines Agency.
FiberCell developed and patented a novel method for generating gas delivery to hollow fiber cartridges. Instead of passively exchanging gas with a medium and flowing that medium through the cartridge, it delivers alternating amounts of medium and gas directly to the interior of the reactor. Rather than using pumps, gravity feed is utilized to circulate the medium in both directions. A device using these technologies would be an entirely new concept in bioreactor operating principles. This was the subject of the company’s MIPS project.
MIPS Project
Validation of Large Scale Hollow Fiber Bioreactor
Project #
4713
|
MIPS Round
47
|
Starting Date:
Feb 2011
MIPS Project Challenge:
The goal of this MIPS project was to construct a prototype of FiberCell’s large-scale, hollow bioreactor system and conduct performance validation.
Project Scope:
Through this MIPS project, a prototype was built and evaluated. FiberCell Systems utilized Mtech’s Biopharmaceutical Advancement Facility (BAF) for lab space, equipment and expertise to make the project possible.
Results:
Proof of principle for the basic function of the bioreactor operating principles was established. Ongoing work continues on optimizing culture conditions and operating parameters with an ultimate goal of establishing cGMP compliance.
Principal Investigator:
Dean
Mann
Professor, Clinical Pathology
Project Manager:
John
Cadwell
President and CEO
Technologies:
Biotechnology / Genetic Engineering
