MARYLAND INDUSTRIAL PARTNERSHIPS

MIPS Projects

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MIPS Round 

48

August

 

2011

August 1, 2011

Aparna Biosciences

Rockville

 | 

Montgomery

 County

Project:

Development of branched HK anti-malarial peptides

Principal Investigator:

John
 
Sacci Jr.
Associate Professor

Technologies:

Biotechnology / Genetic Engineering

MIPS Round 

48

August

 

2011

August 1, 2011

GlycoPure, Inc.

Cambridge

 | 

Dorchester

 County

Project:

Enzymatic conversion of chitin to glucosamine

Principal Investigator:

William
 
Bentley
Professor

Technologies:

Biotechnology / Genetic Engineering

MIPS Round 

48

July

 

2012

July 1, 2012

Xcision Medical Systems, LLC.

Columbia

 | 

Howard

 County

Project:

Radiosurgery of early stage breast cancer

Principal Investigator:

Elizabeth
 
Nichols
Assistant Professor/Clinical Director, Radiation Oncology, University of Maryland School of Medicine

Technologies:

Medical Instrumentation / Equipment

Xcision Medical Systems is a medical technology company developing advanced stereotactic radiotherapy solutions with the potential to dramatically raise the quality of treatments and improve the lives of patients and their loved ones. The company’s solutions are designed to extend the benefits of radiation oncology to more patients and enable noninvasive treatments that allow patients to return to living fuller lives more quickly and less painfully after receiving a cancer diagnosis.

Xcision’s initial focus is on breast cancer, using stereotactic partial breast irradiation to treat patients eligible for breast-conserving therapy. The company’s first product, GammaPod™, is a new, stereotactic radiotherapy system optimized for the treatment of breast cancer in 1-5 sessions.

In the study, researchers identified the geometric and dosimetric accuracy of the breast cup device, identified patients not suitable for GammaPod™, and confirmed patient comfort.

The research generated through this MIPS project resulted in three peer-reviewed publications in 2013 and eight patents.

In 2015, the company obtained the necessary MDE (NRC) licenses, FDA IDE approval to start clinical testing, and NRC source and device registration necessary for ultimate market launch.

Xcision has achieved revenue of $5.2 million and acquired $13.7 million in private funding. Through sales revenue and investment funding, Xcision was able to increase its number of employees from 17 to 22.

The first patient treated using the GammaPod™ occurred on 3/8/16. The IRBapproved clinical trial under the FDA IDE approval completed enrollment in August, 2017. Xcision has submitted application to the FDA for full clearance.

Both pre-clinical and clinical testing are crucial for the GammaPod device to gain FDA clearance and market adoption. Through the first in-human clinical testing, we verified that the GammaPod system is capable of delivering a high focal dose to a target in the breast with low doses to surrounding structures and organs such as the lung, heart, and normal breast tissue.
Faculty members at the University of Maryland, Baltimore invented a method and device for delivering stereotactic radiotherapy specifically for breast cancer. By licensing this technology from UMB and collaborating with the PI and his research team, Xcision developed a new, breast-specific stereotactic radiotherapy machine, the GammaPodTM . The GammaPod uses tens of thousands of radiation beams to focus the radiation at the tumor to kill tumor cells.

MIPS Round 

48

August

 

2011

August 1, 2011

Information Technologies Curves

Gaithersburg

 | 

Montgomery

 County

Project:

Smart Algorithms for Managing Ridesharing Services

Principal Investigator:

Elise
 
Miller-Hooks
Associate Professor, Department of Civil and Environmental Engineering

Technologies:

Software Development

Information Technologies Curves, or IT Curves®, develops state-of-the-art transportation and logistics management software serving enterprises in over 30 cities in the U.S. IT Curves’ software allows enterprises to monitor and manage mobile resources (which operate outside of the office) with the same level of accuracy as inoffice staff and resources. IT Curves’ system allows enterprises such as taxi, limousine, shuttle, campus bus systems, trucking, and other logistics management enterprises to accurately monitor, assign tasks, verify completion of the task, and process payments for these resources while on the road. IT Curves uses standard, off-the-shelf cellular phones and tablets, wireless data communication, accurate GPS positioning, and built-in navigation to enable mobile resources to be managed as an integral part of the company at all times.

The MIPS program is a very effective program to encourage the integration of the academic research and resources with local companies to ignite growth in various industries. We were pleased to see the university’s desire for fresh problems to solve as our industry is seeking to move into the future of increased efficiency. MIPS is a very well-managed and excellent program. Our relationship with our principal investigator was excellent and we found the research team extremely interested in the industrial use of their academic experience and very much capable of understanding the commercial problem we described. Our company has converted the results of our joint work to into tangible business success.

MIPS Round 

48

August

 

2011

August 1, 2011

FLAVORx INC

Columbia

 | 

Howard

 County

Project:

Flavorant Stability Testing

Principal Investigator:

William
 
LaCourse
Chair & Professor

Technologies:

Chemical Engineering / Chemistry

MIPS Round 

48

August

 

2011

August 1, 2011

Opticul diagnostics

Rockville

 | 

Montgomery

 County

Project:

MRSA/MSSA immediate detection in admitted patients

Principal Investigator:

Richard
 
Venezia
Professor

Technologies:

Medical Instrumentation / Equipment

MIPS Round 

48

August

 

2011

August 1, 2011

Green Logic

Bethesda

 | 

Montgomery

 County

Project:

Fish Scraps to Liquid Fertilizer

Principal Investigator:

Y. Martin
 
Lo
Associate Research Scientist

Technologies:

Chemical Engineering / Chemistry

MIPS Round 

48

August

 

2011

August 1, 2011

Leadership Health LLC

Hollywood

 | 

Saint Mary’s

 County

Project:

Enabling the Expansion of Physical Therapy Clinics

Principal Investigator:

Jae Kun
 
Shim
Assistant Professor

Technologies:

Bio / Med / Health InfoTech

MIPS Round 

48

August

 

2011

August 1, 2011

GreenSpacers, Inc.

Columbia

 | 

Baltimore City

 County

Project:

Growing Fresh Air with Soil-Free Plants

Principal Investigator:

Thomas
 
Handwerker
Professor

Technologies:

Agriculture / Poultry Science

MIPS Round 

48

August

 

2011

August 1, 2011

Stress Indicators Inc

Gaithersburg

 | 

Montgomery

 County

Project:

HR SmartBolts Production Automation

Principal Investigator:

Chandrasekhar
 
Thamire
Senior Keystone Lecturer, Department of Mechanical Engineering

Technologies:

Factory Automation

Stress Indicators was established with the goal of innovating and developing visual indication systems to meet the needs of commercial and industrial users. The company’s proprietary Visual Indication technology can be implemented into a wide variety of applications and products.

Stress Indicators’ SmartBolts® product enables users to visually check that critical bolts are properly tightened. The technology accurately displays bolt tension by measuring the elongation of a bolt and converting it into a visual indication.

UMD researchers provided the company with a working model of an automated HR SmartBolts assembly system and a complete set of drawings for a full-scale machine. Stress Indicators evaluated the performance of the model to determine how to set up production of SmartBolts and create a new production process.

When Stress Indicators began its MIPS project, the company was introduced to a student that went on to become the company’s first employee in June, 2010.

The UMD students who worked on this project for us, particularly Babak Eslami and Karim Najjar, have become experts on our HR SmartBolts product. They have significantly advanced our understanding of its components, materials and processes. Their dedication, enthusiasm and determination over a two-year period has been of enormous benefit and will greatly help our company growth by enabling us to offer this new, advanced tension-indicating bolt product.

MIPS Round 

48

August

 

2011

August 1, 2011

Optimal Solutions Group, LLC

College Park

 | 

Prince George’s

 County

Project:

QI2D Collaborative System

Principal Investigator:

Lise
 
Getoor
Associate Professor, Department of Computer Science

Technologies:

Software Development

Optimal Solutions Group, LLC (Optimal) is a small, innovative economic and policy analysis research and software development firm located at the University of Maryland’s Discovery District. Optimal has conducted over 200 evaluations, nationally and in 28+ countries incorporating research rigor and innovative technology tools, such as business intelligence software, integrated data repositories, and machine-learning algorithms.

The project is being considered as a healthcare clinical decision tool for facilitating the rapid assessment and diffusion of continuous quality improvement initiatives.

The goal was to standardize clinical quality assessments and reduce the number of clinical staff needed to conduct administrative tasks.

MIPS was instrumental in the evolution of ReveloTM in augmenting clinician decisionmaking. The total time and costs to conduct health reviews was reduced by at least 50% and the quality of the reporting improved.

MIPS Round 

48

August

 

2011

August 1, 2011

AHPharma Food Safety Products, Inc.

Salisbury

 | 

Wicomico

 County

Project:

Radiant Floor Heat Technology in Chicken Houses

Principal Investigator:

Jeannine
 
Harter-Dennis
Associate Professor

Technologies:

Agriculture / Poultry Science

The mission of AHPharma is to conduct private research for the agriculture industry and reinvest in the core business of the design, development, and commercialization of new technologies for improving animal agriculture production, nutrition, health, energy savings and housing techniques.

AHPharma’s radiant floors are designed to provide heat closer to bird activity via hot-water piping. By only emitting heat where it is needed, growers can reduce propane usage by up to 75 percent.

The company’s LED lighting system for poultry houses, called AviLighting®, reduces energy cost for growers by up to 94 percent per year over incandescent bulbs.

The Radiant & Manure Burning Heat System, (funded by MIPS-DNR), provided an efficiently engineered, cost-effective prototype that the poultry industry will be able to employ within the normal grow-out system, without disruption to normal BMPs (best management practices). The system is being reviewed by national environmental agencies as a method of improving animal welfare, human-worker welfare and grower profitability as well as reduce atmospheric ammonia releases from chicken-rearing houses.

MIPS provides an avenue for the poultry industry to get on a path of sustainable agriculture, produce energy savings that result in quick payback and significant grower profits, provide technology needed to meet EPA regulations to have a positive impact on Chesapeake Bay Restoration, and provide a much-needed boost in the Maryland jobs market, not only in the manufacturing of new technology systems, but in the marketing, installation, and maintenance of these systems as well.

MIPS Round 

47

February

 

2011

February 1, 2011

Blackrock Algae, LLC

Perry Hall

 | 

Baltimore

 County

Project:

Improving Water Quality in the Bay

Principal Investigator:

Patrick
 
Kangas
Associate Professor

Technologies:

Environmental Technology / Science

MIPS Round 

47

February

 

2011

February 1, 2011

Medcura, Inc.

College Park

 | 

Prince George’s

 County

Project:

Hemogrip: Reversible Hemorrhage Control

Principal Investigator:

Srinivasa
 
Raghavan
Professor, Department of Chemical and Biomolecular Engineering

Technologies:

Biotechnology / Genetic Engineering

Medcura (formerly gel-e Inc.), a privately held, clinical-stage medical device company, develops a broad range of hemostatic and wound treatment products, including bandages for the treatment of routine cuts and scrapes, foams and putties for traumatic and military injuries, and surgical gels and powders.

As a result of this project, the company and researchers became comfortable with synthesizing, scaling-up, purifying and characterizing a range of hydrophobically modified (hm) chitosan bandages for use in the control of traumatic bleeding. Multiple formulations of hm-chitosans were synthesized and optimized on the benchtop (via rheology) to gel blood rapidly, and adhere to tissue strongly and reversibly. Bandages of hm-chitosan were manufactured; they were tested in vitro via tissue adhesion studies and evaluated on severe arterial bleeds. gel-e® was shown to have significantly superior tissue adhesion relative to a range of key market competitor products in the trauma and surgical spaces.  gel-e® also showed significant in vivo efficacy relative to unmodified chitosan bandages, which represent key competitors in the trauma hemostat marketplace. Three invention disclosures and two publications have been created as a result of this continuing research. This helps to strengthen the company’s competitive position in the marketplace and is providing interest from the medical community (Medcura’s key customers) in both the core technology and resulting commercial products. Last, but not least, the company was able to collect much of the key data that has gone into the company’s first FDA 510(k) submission.

In July, 2015, Medcura received FDA clearance for its technology, indicated for use as a vascular closure device, where it rapidly controls bleeding that occurs when accessing veins or arteries for various medical treatments and applications. In July, 2017, Medcura raised $3.1 million in a private financing, led by early-stage investment funds and life science investors.

Additional Mtech/UMD Programs Utilized:
University of Maryland $75K Business Plan Competition, VentureAccelerator, Technoloy Advancement Program (TAP) incubator

Medcura simply would not be alive and thriving without the support of MIPS. Our 2008 MIPS grant was the first substantial research grant that we received, and that funding has created a platform for our company to raise over $1.7 million in non-dilutive funding and reach a first regulatory milestone. Medcura hopes to continue to serve as an example of a real-world manifestation of the vision for the MIPS program.

MIPS Round 

47

February

 

2011

February 1, 2011

Universal Security Instruments

Owings Mills

 | 

Baltimore

 County

Project:

IoPhic Advanced Fire Technology

Principal Investigator:

James
 
Milke
Professor and Associate Chair, Department of Fire Protection Engineering

Technologies:

Fire Protection Engineering

Universal Security Instruments Inc. (NYSE Amex: UUU) is an international designer, developer, manufacturer and marketer of high quality, professional and easy-toinstall home safety and security products. From its founding in 1969, UNIVERSAL® has grown to be an industry leader, providing residential fire safety and security products from its own overseas manufacturing facility. The company presently has government regulatory approvals to distribute in 30 countries.

Beginning in 1973, UNIVERSAL began manufacturing smoke and fire alarms and has developed a complete assortment of UL-Listed battery powered and hardwired alarms, with various patented features. UNIVERSAL began shipping carbon monoxide alarms in 2000. In 2013, the company’s product line was expanded to include the industry’s first and only 10-Year Permanent Power sealed battery alarms. Powered by Duracell® Duralock Power Preserve Technology™, UNIVERSAL alarms are lithium-free, providing a safer, more eco-friendly solution to low-battery chirps.

UNIVERSAL has become one of the largest manufacturers of Smoke and Carbon Monoxide Alarms in the world. In July, 2003, UNIVERSAL was listed on the American Stock Exchange.

Researchers found that UNIVERSAL’S IoPhic-based alarms were significantly less likely to respond to nuisances. This result is helping USI market its new line of smoke alarms, along with combination smoke and carbon monoxide alarms. UNIVERSAL has now incorporated this breakthrough technology into its line of lithium-free, 10-Year Permanent Power Smart Alarms. By developing alarms with room-by-room placement, UNIVERSAL takes the guesswork out of proper placement and designates the best technology type where it is needed.

MIPS Round 

47

February

 

2011

February 1, 2011

Luke's Premier Foods, LLC

Princess Anne

 | 

Somerset

 County

Project:

Scale-up process for Heirloom Tomato Juice &Nectar

Principal Investigator:

Jurgen
 
Schwarz
Director

Technologies:

Food Processing

MIPS Round 

47

February

 

2011

February 1, 2011

FiberCell Systems, Inc

Frederick

 | 

Frederick

 County

Project:

Validation of Large Scale Hollow Fiber Bioreactor

Principal Investigator:

Dean
 
Mann
Professor, Clinical Pathology

Technologies:

Biotechnology / Genetic Engineering

FiberCell Systems offers hollow fiber bioreactor systems to academic and biotechnology markets. The company’s bioreactors utilize new, state-of-the-art filtration rates that offer many advantages over conventional cell culture methods, and are used by NASA at the International Space Station and endorsed by the European Medicines Agency.

FiberCell developed and patented a novel method for generating gas delivery to hollow fiber cartridges. Instead of passively exchanging gas with a medium and flowing that medium through the cartridge, it delivers alternating amounts of medium and gas directly to the interior of the reactor. Rather than using pumps, gravity feed is utilized to circulate the medium in both directions. A device using these technologies would be an entirely new concept in bioreactor operating principles. This was the subject of the company’s MIPS project.

Proof of principle for the basic function of the bioreactor operating principles was established. Ongoing work continues on optimizing culture conditions and operating parameters with an ultimate goal of establishing cGMP compliance.

MIPS provided FiberCell with both the seed money to test and evaluate a new type of bioreactor and connections with Maryland resources to make the project a success.

MIPS Round 

47

February

 

2011

February 1, 2011

Differential Dynamics Corporation

Owings Mills

 | 

Baltimore

 County

Project:

Wind Turbine with Controlled Speed and Torque

Principal Investigator:

Weidong
 
Zhu
Professor of Mechanical Engineering

Technologies:

Energy

MIPS Round 

47

February

 

2011

February 1, 2011

OmniSpeech LLC

College Park

 | 

Prince George’s

 County

Project:

Speech vs. Noise using Articulatory Information

Principal Investigator:

Shihab
 
Shamma
Professor, Department of Electrical and Computer Engineering & Institute for Systems Research (ISR)

Technologies:

Communications

OmniSpeech LLC develops speech extraction technology for cellular and similar communications. The company has developed a method for extracting speech from noise, making communications such as cell phone conversations clear, even in environments such as high wind or large crowds. The technology can be applied to a wide range of audio and voice-oriented commercial devices, including hearing aids.

In 2012, OmniSpeech raised investment of up to $2 million from private investors. The company also won a $495,000 Phase 2 SBIR from the National Science Foundation. In September, 2017, the company announced that its OmniClearTM technology was included in the latest Alcatel MOVE TIME smart watch.

Additional Mtech/UMD Programs Utilized:
University of Maryland $75K Business Plan Competition, VentureAccelerator, Technology Advancement Program (TAP) incubator

MIPS is a wonderful program, especially for early stage companies. Our MIPS project has enabled us to address an issue that is really important for our technology.
OmniSpeech won the high technology category and $25,000, as well as a $15,000 Warren Citrin Social Impact Award in the 2010 University of Maryland $75K Business Plan Competition. The company also won the grand prize in the Rockville Economic Development Inc. (REDI) StartRight! Women’s Business Plan Competition, receiving $10,000 from EagleBank, a $10,000 advertising package from Comcast Spotlight, one year of virtual incubator membership from the Montgomery County Department of Economic Development, and nine months of a customized virtual office solution from Intelligent Office. OmniSpeech also won the 2010 $50,000 SAIC-VentureAccelerator Competition.

MIPS Round 

47

February

 

2011

February 1, 2011

Speech ConversionTechnologies, Inc

Silver Spring

 | 

Montgomery

 County

Project:

Creation of Distinct Annotated News Corpora

Principal Investigator:

William
 
Idsardi
Associate Professor

Technologies:

Communications

MIPS Round 

47

February

 

2011

February 1, 2011

Beyond Meat

El Segundo, CA 90245

 | 

out-of-state

 County

Project:

Commercialization of Novel Plant Protein Products

Principal Investigator:

Y. Martin
 
Lo
Associate Research Scientist

Technologies:

Food Processing

MIPS Round 

47

February

 

2011

February 1, 2011

Cerona Networks Corporation

Frederick

 | 

Frederick

 County

Project:

Enhanced SAMA VSAT with FMCSA and DCA capability

Principal Investigator:

John
 
Baras
Professor

Technologies:

Communications

MIPS Round 

47

February

 

2011

February 1, 2011

FlexEl

College Park

 | 

Prince George’s

 County

Project:

Battery Management System for Thin-Film Batteries

Principal Investigator:

Victor
 
Granatstein
Professor

Technologies:

Electrical / Power Engineering

MIPS Round 

47

February

 

2011

February 1, 2011

Under Armour

Baltimore

 | 

Baltimore City

 County

Project:

Adaptation of running to a new shoe design

Principal Investigator:

Jae Kun
 
Shim
Assistant Professor, Kinesiology

Technologies:

Other

Under Armour® (NYSE: UA) is a leading developer, marketer and distributor of branded performance apparel, footwear and accessories. The company’s products are sold worldwide and worn by athletes at all levels, from youth to professionals, on playing fields around the globe. The Under Armour® global headquarters is in Baltimore, Md., with European headquarters in Amsterdam’s Olympic Stadium, and additional offices in Denver, Hong Kong, Toronto, and Guangzhou, China.

MIPS Round 

47

February

 

2011

February 1, 2011

HY-TEK Bio, LLC.

Dayton

 | 

Howard

 County

Project:

Algae-based CO2 Scrubber for Flue Gases

Principal Investigator:

Feng
 
Chen
Professor

Technologies:

Environmental Technology / Science

HY-TEK Bio is an early stage company developing a patent-pending system to remove carbon dioxide and other harmful greenhouse gases from smoke stack flue gas using a unique strain of algae while producing valuable byproducts from the algae. The company’s system mitigates greenhouse gas from flue gases by injecting the flue gas into a tank full of a unique strain of algae. The tank is a patent-pending, closed bioreactor produced in-house from a lamination of Mylar and Kevlar. This patent-pending construct allows the bioreactors to be produced inexpensively while being extremely light weight. In addition, patent-pending LED Grow Lights are used along with a nutrient developed in-house, made from fresh chicken manure and a blend of other proprietary components.

The algae feeds on the CO2 and NOx in the flue gas, as well as on the nutrient. CO2 consumption is enhanced through the use of proprietary LED Grow Light technology, yielding minimal greenhouse gas emissions and high yields of high-value algal biomass. The process produces little to no CO2 or NOx emissions, while enhancing the lipid-oil production in the algae as well as a by-product of Lutein-Zeaxanthin, an ultra-antioxidant that is in high demand in the market place. The algal biomass can be sold to brokers, who place the biomass into markets that produce Lutein-Zeaxanthin-based products, bio-plastics, skin care products, cosmetic and paint thickeners, additives for human and animal food products, and biofuel.

We are moving to an entirely new concept in closed bioreactor design using our patentpending Mylar/Kevlar tank structure, our unique “modulated” LED Grow Light technology, our patent-pending air injection system and our special, high-value chicken manurebased nutrient. These concepts will revolutionize closed bioreactors and the way the world mitigates greenhouse gas emissions.
HY-TEK Bio is a classic example of the Maryland Industrial Partnerships Program making a difference in helping a small company bring big ideas to market.